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In very rare cases of depression where all other treatments have failed, careful neurosurgical interruption of brain pathways has been shown to help about 50% of patients.  The neurosurgical procedures are done under the control of exact three dimensional measurements (stereotactic) so that the interruption of brain pathways is precisely defined and limited.  The techniques are surprisingly safe and seldom cause complications in the form of personality change or epilepsy.  Death as a result of this surgery is rare.
Although clearly not to be undertaken lightly, psychosurgery has a place in the treatment of the most difficult cases of depression. Psychosurgery should never be recommended until and unless all other treatments had been given a full trial and found to be ineffective.  In addition, psychosurgery should never be recommended until at least 2 years have passed, during which the full spectrum of alternative treatments had been tried and a spontaneous remission had failed to appear.  Even then, the surgery should be performed only for patients with severe depression that is causing them extreme distress or disability.
Psychosurgery: A Last Resort For Treatment Of Depression