Antidepressant medications are
the cornerstone of treatment of major depression and often play a role
in the treatment of less severe depression. Indications for the
use of antidepressant medications are usually straightforward and involve the presence of depressive mood, thoughts, behaviors, and physical symptoms.
Sometimes
depressions are hidden, or “masked”- patients may complain
of pain such as headache, backache, or stomachache instead of sadness;
or they may insist that they feel fine, but fail to go to work or look
quite upset.
They may
first notice panic attacks or phobias (fears they recognize as
unreasonable); or they may become obsessed with fears or pestered by compulsive
rituals; or they may abuse alcohol or other drugs in attempts at
self-treatment of depression. Depression may also be signaled by
other “atypical” physical or emotional complaints.
Diagnose Your Depression First
The accurate diagnosis of depression is a necessary step in the
process of selecting appropriate medications or other treatments.
A thorough history is essential and a physical examination and lab
tests are often necessary to select the depression treatment.
The clinician should consider the patient’s past history of
depression and response to earlier treatments, family history of
depression and treatment response, concurrent medical problems and
their treatments, occupational and social impairment, severity of
depression, risk of suicide, age, importance of speedy recovery,
patient reliability, and preference for treatment.
The Depression Medication Classes
Several different classes of antidepressant medications are available. Tricyclic antidepressants
and newer drugs with different chemical structures but similar
effectiveness are the major antidepressant medications. They are
often referred to as cyclic antidepressants because they contain one or
more cyclic rings in their structure (a tricyclic has 3 such
rings). Monoamine oxidase inhibitors (MAOI’s) make up the other main class of medications for treatment of depression. Lithium,
used primarily in the treatment of mania and depression when those two
disorders occur together or in sequence, may also be effective in cases
where depression is the only problem. A number of other
medications are sometimes added to the three main classes of medication
(cyclic antidepressants, MAOI’s, Lithium).
Depression Medication Side Effects
Antidepressant medications are generally safe and effective when used as directed. But all medications are double edged swords with unwanted side effects
as well as beneficial main effects. Most antidepressant side
effects are minor annoyances and many side effects decrease in severity
as patient’s bodies grow accustomed to the medication. When
depression is treated with medications, there is almost always some
minor cost in terms of side effects to pay for the major benefit of
relief of depression. Keeping the costs low and the benefits high
is important and can almost always be accomplished in a cooperative
relationship between patient and doctor.
Types Of Depression Medication: